Thymosin Alpha-1 10mg

Thymosin Alpha-1 (Tα1) is a 28-amino-acid, N-terminally acetylated peptide originally isolated from thymosin fraction 5, a calf thymus extract. It is one of the best-characterised thymic peptides in immunology research. Contexx Research supplies Thymosin Alpha-1 in Canada as a 10 mg lyophilized research peptide.

Thymosin Alpha-1 specifications

Research overview

Tα1 was isolated and sequenced by Allan Goldstein’s group in the 1970s. It comes from the N-terminus of prothymosin α. Mechanistic studies point to the innate immune system: a 2004 study in Blood showed that Tα1 activates dendritic cells through Toll-like receptor signalling (including the MyD88-dependent pathway), with downstream effects on Th1 responses in murine models [1].

In-vitro work with human cells has refined that picture. A 2015 study examined how Tα1 affects human monocyte-derived dendritic cells stimulated with viral and bacterial TLR agonists, and described context-dependent effects on cytokine production [2].

A 2016 review summarises Tα1’s immunomodulatory mechanisms, including its effects on T-cell maturation, dendritic-cell function and cytokine networks [3]. In the laboratory, Tα1 is used in dendritic-cell and T-cell culture assays, TLR signalling studies and as a reference thymic peptide.

Selected references

1. Romani L et al. Blood. 2004. PubMed 14982877
2. Giacomini E et al. Expert Opin Biol Ther. 2015. PubMed 26096650
3. King R et al. Vitam Horm. 2016. PubMed 27450734

Storage and handling

Thymosin Alpha-1 ships as a lyophilized (freeze-dried) powder. Dry material is far more stable than material in solution, so keep it in its dry, sealed state until you need it.

• Store unopened vials of Thymosin Alpha-1 at −20 °C, dry and protected from light. Let the vial reach room temperature before opening to limit condensation.
• Prepare stock solutions in a solvent suited to your assay, label them with concentration and date, and keep them at 2–8 °C for short-term use.
• For longer storage of solutions, divide them into single-use aliquots and freeze them; avoid repeated freeze–thaw cycles.
• Handle with gloves and eye protection, following your laboratory’s standard chemical-hygiene practice.

See our guide to storing lyophilized peptides in the lab for more detail.

Quality and testing

Contexx Research independently tests every batch it releases. A lot-specific COA for Thymosin Alpha-1 isn’t linked on this page yet. For questions about testing, contact info@contexxresearch.ca.

We don’t list purity figures in this description; the lot COA is the reference for identity and purity. Researchers should confirm identity and concentration with their own analytical methods where their protocol requires it.

Frequently asked questions

What’s included when I order Thymosin Alpha-1 10 mg?

One sealed vial containing 10 mg of Thymosin Alpha-1 as a lyophilized powder. Reconstitution solution is sold separately.

Does Thymosin Alpha-1 come with a Certificate of Analysis (COA)?

Every batch Contexx Research releases is independently tested. A lot-specific COA isn’t linked on this page yet; for testing questions, contact info@contexxresearch.ca.

How fast is shipping in Canada?

Orders are processed Monday to Friday, and most orders ship within 24 hours from Mississauga, Ontario, in secure, tamper-evident packaging. Orders placed on Friday afternoon (after the 12:00 PM ET cut-off) ship on Monday, when Canada Post resumes pickup, or on the next business day if Monday is a statutory holiday. Once your order ships, delivery typically takes 1–3 business days in Ontario and Quebec and 2–6 business days in the rest of Canada, and a tracking number is emailed to you. Orders over $250 CAD shipped within Canada qualify for free standard shipping. See our Shipping Policy for details.

How should Thymosin Alpha-1 be stored?

Store unopened vials at −20 °C, dry and protected from light. After reconstitution, keep solutions at 2–8 °C for short-term use, or freeze single-use aliquots and avoid repeated freeze–thaw cycles.

What does “research use only” mean?

“Research use only” means Thymosin Alpha-1 is sold only as a reference material for in-vitro laboratory and analytical research by qualified professionals. It is not for use in humans or animals, not for diagnostic use, and not a drug, natural health product, food, supplement or cosmetic.

Research use only

Thymosin Alpha-1 is sold by Contexx Research Inc. strictly as a reference material for in-vitro laboratory research and analytical use by qualified professionals. It is not a drug, natural health product, food, dietary supplement or cosmetic. It is not intended for use in humans or animals, for diagnostic purposes, or for ingestion or any other form of administration to a living organism. Nothing on this page describes or implies any effect in humans or animals. Purchasers are responsible for handling, storage and disposal in line with applicable laws and their institution’s policies. By ordering, you confirm that you are purchasing for legitimate laboratory research and agree to our Terms and Conditions.