Mazdutide (LY3305677, IBI362) is a synthetic, acylated peptide that acts as a dual agonist at the GLP-1 receptor (GLP-1R) and the glucagon receptor (GCGR), and is structurally related to the gut hormone oxyntomodulin. Contexx Research supplies Mazdutide in Canada as a 10 mg lyophilized reference material for in-vitro receptor pharmacology research.
Mazdutide specifications
| Compound | Mazdutide (LY3305677; IBI362) |
|---|---|
| Vial size | 10 mg |
| Form | Lyophilized powder |
| Purity | See lot COA |
| Compound class | Acylated GLP-1 / glucagon receptor dual agonist peptide |
| CAS number | 2259884-03-0 |
| Molecular formula | C207H317N45O65 |
| Molecular weight | 4476 g/mol |
| Storage (unopened) | −20 °C, dry, protected from light |
Research overview
Oxyntomodulin is a natural proglucagon-derived peptide that weakly activates both GLP-1R and GCGR. Mazdutide was designed as a long-acting oxyntomodulin-like analogue. Its sequence is modified to balance activity at the two receptors, and a fatty-acid side chain binds albumin to extend its half-life. Both receptors are class B GPCRs that signal mainly through Gαs and cAMP, but they differ in tissue distribution and downstream biology.
A 2025 review in Drugs summarises Mazdutide’s structure, receptor pharmacology and development history [1]. In preclinical research, a 2025 study in EBioMedicine combined mouse models with multi-omics analysis to examine GLP-1R/GCGR dual agonism in the brain [2].
In vitro, Mazdutide is profiled in GLP-1R- and GCGR-expressing cell lines to compare cAMP potency and signalling bias at each receptor. It is also used as a reference standard for LC-MS identification and peptide-stability methods.
Selected references
- Shirley M Drugs. 2025. PubMed 41028652
- Dong W et al. EBioMedicine. 2025. PubMed 40479843
Storage and handling
Mazdutide ships as a lyophilized (freeze-dried) powder. Dry material is far more stable than material in solution, so keep it in its dry, sealed state until you need it.
- Store unopened vials of Mazdutide at −20 °C, dry and protected from light. Let the vial reach room temperature before opening to limit condensation.
- Prepare stock solutions in a solvent suited to your assay, label them with concentration and date, and keep them at 2–8 °C for short-term use.
- For longer storage of solutions, divide them into single-use aliquots and freeze them; avoid repeated freeze–thaw cycles.
- Handle with gloves and eye protection, following your laboratory’s standard chemical-hygiene practice.
See our guide to storing lyophilized peptides in the lab for more detail.
Quality and testing
Contexx Research independently tests every batch it releases. A lot-specific COA for Mazdutide isn’t linked on this page yet. For questions about testing, contact info@contexxresearch.ca.
We don’t list purity figures in this description; the lot COA is the reference for identity and purity. Researchers should confirm identity and concentration with their own analytical methods where their protocol requires it.
Frequently asked questions
What’s included when I order Mazdutide 10 mg?
One sealed vial containing 10 mg of Mazdutide as a lyophilized powder. Reconstitution solution is sold separately.
Does Mazdutide come with a Certificate of Analysis (COA)?
Every batch Contexx Research releases is independently tested. A lot-specific COA isn’t linked on this page yet; for testing questions, contact info@contexxresearch.ca.
How fast is shipping in Canada?
Orders are processed Monday to Friday, and most orders ship within 24 hours from Mississauga, Ontario, in secure, tamper-evident packaging. Orders placed on Friday afternoon (after the 12:00 PM ET cut-off) ship on Monday, when Canada Post resumes pickup, or on the next business day if Monday is a statutory holiday. Once your order ships, delivery typically takes 1–3 business days in Ontario and Quebec and 2–6 business days in the rest of Canada, and a tracking number is emailed to you. Orders over $250 CAD shipped within Canada qualify for free standard shipping. See our Shipping Policy for details.
How should Mazdutide be stored?
Store unopened vials at −20 °C, dry and protected from light. After reconstitution, keep solutions at 2–8 °C for short-term use, or freeze single-use aliquots and avoid repeated freeze–thaw cycles.
What does “research use only” mean?
“Research use only” means Mazdutide is sold only as a reference material for in-vitro laboratory and analytical research by qualified professionals. It is not for use in humans or animals, not for diagnostic use, and not a drug, natural health product, food, supplement or cosmetic.
Research use only
Mazdutide is sold by Contexx Research Inc. strictly as a reference material for in-vitro laboratory research and analytical use by qualified professionals. It is not a drug, natural health product, food, dietary supplement or cosmetic. It is not intended for use in humans or animals, for diagnostic purposes, or for ingestion or any other form of administration to a living organism. Nothing on this page describes or implies any effect in humans or animals. Purchasers are responsible for handling, storage and disposal in line with applicable laws and their institution’s policies. By ordering, you confirm that you are purchasing for legitimate laboratory research and agree to our Terms and Conditions.
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