Kisspeptin-10 10mg

Kisspeptin-10 is the C-terminal decapeptide (residues 45–54) of human kisspeptin, the product of the KISS1 gene, and the shortest fragment with full agonist activity at the kisspeptin receptor (KISS1R, formerly GPR54). Contexx Research supplies Kisspeptin-10 in Canada as a 10 mg lyophilized peptide, third-party tested for identity and content.

Kisspeptin-10 specifications

Research overview

In 2001, Kotani and colleagues showed that peptides encoded by the metastasis-suppressor gene KiSS-1, which they named kisspeptins, are the natural ligands of the orphan G protein-coupled receptor GPR54. Kisspeptin-10 activated the receptor with potency similar to longer forms [1]. KISS1R couples mainly through Gαq/11, leading to phospholipase C activation and intracellular calcium mobilisation.

Genetic studies later placed kisspeptin–GPR54 signalling at the top of the hypothalamic-pituitary-gonadal axis, and it became one of the most active areas of reproductive neuroendocrinology. Seminara reviews the discovery of this pathway [2].

Kisspeptin-10 is also studied outside the reproductive axis. A 2018 study reported that it stimulated osteoblast differentiation in vitro through GPR54-mediated regulation of BMP2 [3]. Laboratory uses include KISS1R binding and calcium assays, GnRH-neuron and cell-line studies and structure–activity work on kisspeptin analogues.

Selected references

1. Kotani M et al. J Biol Chem. 2001. PubMed 11457843
2. Seminara SB et al. J Neuroendocrinol. 2008. PubMed 18601695
3. Son HE et al. Sci Rep. 2018. PubMed 29391507

Storage and handling

Kisspeptin-10 ships as a lyophilized (freeze-dried) powder. Dry material is far more stable than material in solution, so keep it in its dry, sealed state until you need it.

• Store unopened vials of Kisspeptin-10 at −20 °C, dry and protected from light. Let the vial reach room temperature before opening to limit condensation.
• Prepare stock solutions in a solvent suited to your assay, label them with concentration and date, and keep them at 2–8 °C for short-term use.
• For longer storage of solutions, divide them into single-use aliquots and freeze them; avoid repeated freeze–thaw cycles.
• Handle with gloves and eye protection, following your laboratory’s standard chemical-hygiene practice.

See our guide to storing lyophilized peptides in the lab for more detail.

Quality and testing

Kisspeptin-10 is third-party tested for identity and content. For questions about testing, contact info@contexxresearch.ca.

We don’t list purity figures in this description; the lot COA is the reference for identity and purity. Researchers should confirm identity and concentration with their own analytical methods where their protocol requires it.

Frequently asked questions

What’s included when I order Kisspeptin-10 10 mg?

One sealed vial containing 10 mg of Kisspeptin-10 as a lyophilized powder. Reconstitution solution is sold separately.

Does Kisspeptin-10 come with a Certificate of Analysis (COA)?

This product is third-party tested for identity and content. For questions about the current lot’s testing, contact info@contexxresearch.ca.

How fast is shipping in Canada?

Orders are processed Monday to Friday, and most orders ship within 24 hours from Mississauga, Ontario, in secure, tamper-evident packaging. Orders placed on Friday afternoon (after the 12:00 PM ET cut-off) ship on Monday, when Canada Post resumes pickup, or on the next business day if Monday is a statutory holiday. Once your order ships, delivery typically takes 1–3 business days in Ontario and Quebec and 2–6 business days in the rest of Canada, and a tracking number is emailed to you. Orders over $250 CAD shipped within Canada qualify for free standard shipping. See our Shipping Policy for details.

How should Kisspeptin-10 be stored?

Store unopened vials at −20 °C, dry and protected from light. After reconstitution, keep solutions at 2–8 °C for short-term use, or freeze single-use aliquots and avoid repeated freeze–thaw cycles.

What does “research use only” mean?

“Research use only” means Kisspeptin-10 is sold only as a reference material for in-vitro laboratory and analytical research by qualified professionals. It is not for use in humans or animals, not for diagnostic use, and not a drug, natural health product, food, supplement or cosmetic.

Research use only

Kisspeptin-10 is sold by Contexx Research Inc. strictly as a reference material for in-vitro laboratory research and analytical use by qualified professionals. It is not a drug, natural health product, food, dietary supplement or cosmetic. It is not intended for use in humans or animals, for diagnostic purposes, or for ingestion or any other form of administration to a living organism. Nothing on this page describes or implies any effect in humans or animals. Purchasers are responsible for handling, storage and disposal in line with applicable laws and their institution’s policies. By ordering, you confirm that you are purchasing for legitimate laboratory research and agree to our Terms and Conditions.