Tesamorelin 5mg / 10mg

Tesamorelin is a synthetic 44-amino-acid analogue of human growth hormone-releasing hormone (GHRH) with a trans-3-hexenoyl group attached to the N-terminal tyrosine. The modification makes it resistant to dipeptidyl peptidase-4 cleavage. Contexx Research supplies Tesamorelin in Canada as a lyophilized peptide in 5 mg and 10 mg vials for GHRH receptor research.

Tesamorelin specifications

Research overview

Native GHRH(1–44) is cleaved quickly between residues 2 and 3 by DPP-4, which inactivates it. Tesamorelin, originally coded TH9507, keeps the full native sequence and adds a trans-3-hexenoic acid to the N-terminus. This protects the peptide from cleavage while preserving its affinity for the GHRH receptor, a Gαs-coupled class B GPCR on pituitary somatotrophs.

The preclinical pharmacology and safety programme for TH9507 was published in 2007. It described receptor activity, stimulation of growth-hormone release in animal models and toxicology findings [1]. Another study in dogs examined pulmonary delivery of the peptide as part of formulation research [2]. A 2006 drug-evaluation review summarises its chemistry and pharmacological profile [3].

In the laboratory, Tesamorelin is used as a stabilised reference GHRH receptor agonist in pituitary-cell cAMP and secretion assays, in peptide-stability studies comparing modified and native GHRH, and as an analytical standard for LC-MS detection of GHRH analogues.

Selected references

1. Ferdinandi ES et al. Basic Clin Pharmacol Toxicol. 2007. PubMed 17214611
2. Jansen M et al. Int J Pharm. 2004. PubMed 15113616
3. Tomlinson B Curr Opin Investig Drugs. 2006. PubMed 17086939

Storage and handling

Tesamorelin ships as a lyophilized (freeze-dried) powder. Dry material is far more stable than material in solution, so keep it in its dry, sealed state until you need it.

• Store unopened vials of Tesamorelin at −20 °C, dry and protected from light. Let the vial reach room temperature before opening to limit condensation.
• Prepare stock solutions in a solvent suited to your assay, label them with concentration and date, and keep them at 2–8 °C for short-term use.
• For longer storage of solutions, divide them into single-use aliquots and freeze them; avoid repeated freeze–thaw cycles.
• Handle with gloves and eye protection, following your laboratory’s standard chemical-hygiene practice.

See our guide to storing lyophilized peptides in the lab for more detail.

Quality and testing

Contexx Research independently tests every batch it releases. A lot-specific COA for Tesamorelin isn’t linked on this page yet. For questions about testing, contact info@contexxresearch.ca.

We don’t list purity figures in this description; the lot COA is the reference for identity and purity. Researchers should confirm identity and concentration with their own analytical methods where their protocol requires it.

Frequently asked questions

What’s included when I order Tesamorelin 5 mg or 10 mg?

One sealed vial containing 5 mg or 10 mg (as selected) of Tesamorelin as a lyophilized powder. Reconstitution solution is sold separately.

Does Tesamorelin come with a Certificate of Analysis (COA)?

Every batch Contexx Research releases is independently tested. A lot-specific COA isn’t linked on this page yet; for testing questions, contact info@contexxresearch.ca.

How fast is shipping in Canada?

Orders are processed Monday to Friday, and most orders ship within 24 hours from Mississauga, Ontario, in secure, tamper-evident packaging. Orders placed on Friday afternoon (after the 12:00 PM ET cut-off) ship on Monday, when Canada Post resumes pickup, or on the next business day if Monday is a statutory holiday. Once your order ships, delivery typically takes 1–3 business days in Ontario and Quebec and 2–6 business days in the rest of Canada, and a tracking number is emailed to you. Orders over $250 CAD shipped within Canada qualify for free standard shipping. See our Shipping Policy for details.

How should Tesamorelin be stored?

Store unopened vials at −20 °C, dry and protected from light. After reconstitution, keep solutions at 2–8 °C for short-term use, or freeze single-use aliquots and avoid repeated freeze–thaw cycles.

What does “research use only” mean?

“Research use only” means Tesamorelin is sold only as a reference material for in-vitro laboratory and analytical research by qualified professionals. It is not for use in humans or animals, not for diagnostic use, and not a drug, natural health product, food, supplement or cosmetic.

Research use only

Tesamorelin is sold by Contexx Research Inc. strictly as a reference material for in-vitro laboratory research and analytical use by qualified professionals. It is not a drug, natural health product, food, dietary supplement or cosmetic. It is not intended for use in humans or animals, for diagnostic purposes, or for ingestion or any other form of administration to a living organism. Nothing on this page describes or implies any effect in humans or animals. Purchasers are responsible for handling, storage and disposal in line with applicable laws and their institution’s policies. By ordering, you confirm that you are purchasing for legitimate laboratory research and agree to our Terms and Conditions.