Cagrilintide 5mg

Cagrilintide is a synthetic, lipidated analogue of the pancreatic hormone amylin, engineered for stability and long receptor residence. Contexx Research supplies Cagrilintide in Canada as a 5 mg lyophilized reference peptide for amylin and calcitonin receptor pharmacology research.

Cagrilintide specifications

Research overview

Amylin is a 37-residue peptide co-secreted with insulin. It signals through amylin receptors (AMY1–3), which form when the calcitonin receptor pairs with one of the receptor activity-modifying proteins RAMP1, RAMP2 or RAMP3. Hay and colleagues’ review in Pharmacological Reviews is the standard reference on amylin receptor composition, ligand selectivity and signalling [1].

Native amylin aggregates and fibrillates readily, which makes it hard to work with in solution. The 2021 Journal of Medicinal Chemistry paper describing cagrilintide’s development explains how researchers addressed this. They substituted residues to reduce fibrillation, added an N-terminal C20 diacid lipid side chain to bind albumin, and characterised the analogue’s potency at amylin and calcitonin receptors in cell-based assays [2].

Cagrilintide is used in vitro as a reference agonist for AMY receptor subtypes and the calcitonin receptor, in cAMP signalling assays and in peptide-stability or LC-MS method development work.

Selected references

1. Hay DL et al. Pharmacol Rev. 2015. PubMed 26071095
2. Kruse T et al. J Med Chem. 2021. PubMed 34288673

Storage and handling

Cagrilintide ships as a lyophilized (freeze-dried) powder. Dry material is far more stable than material in solution, so keep it in its dry, sealed state until you need it.

• Store unopened vials of Cagrilintide at −20 °C, dry and protected from light. Let the vial reach room temperature before opening to limit condensation.
• Prepare stock solutions in a solvent suited to your assay, label them with concentration and date, and keep them at 2–8 °C for short-term use.
• For longer storage of solutions, divide them into single-use aliquots and freeze them; avoid repeated freeze–thaw cycles.
• Handle with gloves and eye protection, following your laboratory’s standard chemical-hygiene practice.

See our guide to storing lyophilized peptides in the lab for more detail.

Quality and testing

Contexx Research independently tests every batch it releases. A lot-specific COA for Cagrilintide isn’t linked on this page yet. For questions about testing, contact info@contexxresearch.ca.

We don’t list purity figures in this description; the lot COA is the reference for identity and purity. Researchers should confirm identity and concentration with their own analytical methods where their protocol requires it.

Frequently asked questions

What’s included when I order Cagrilintide 5 mg?

One sealed vial containing 5 mg of Cagrilintide as a lyophilized powder. Reconstitution solution is sold separately.

Does Cagrilintide come with a Certificate of Analysis (COA)?

Every batch Contexx Research releases is independently tested. A lot-specific COA isn’t linked on this page yet; for testing questions, contact info@contexxresearch.ca.

How fast is shipping in Canada?

Orders are processed Monday to Friday, and most orders ship within 24 hours from Mississauga, Ontario, in secure, tamper-evident packaging. Orders placed on Friday afternoon (after the 12:00 PM ET cut-off) ship on Monday, when Canada Post resumes pickup, or on the next business day if Monday is a statutory holiday. Once your order ships, delivery typically takes 1–3 business days in Ontario and Quebec and 2–6 business days in the rest of Canada, and a tracking number is emailed to you. Orders over $250 CAD shipped within Canada qualify for free standard shipping. See our Shipping Policy for details.

How should Cagrilintide be stored?

Store unopened vials at −20 °C, dry and protected from light. After reconstitution, keep solutions at 2–8 °C for short-term use, or freeze single-use aliquots and avoid repeated freeze–thaw cycles.

What does “research use only” mean?

“Research use only” means Cagrilintide is sold only as a reference material for in-vitro laboratory and analytical research by qualified professionals. It is not for use in humans or animals, not for diagnostic use, and not a drug, natural health product, food, supplement or cosmetic.

Research use only

Cagrilintide is sold by Contexx Research Inc. strictly as a reference material for in-vitro laboratory research and analytical use by qualified professionals. It is not a drug, natural health product, food, dietary supplement or cosmetic. It is not intended for use in humans or animals, for diagnostic purposes, or for ingestion or any other form of administration to a living organism. Nothing on this page describes or implies any effect in humans or animals. Purchasers are responsible for handling, storage and disposal in line with applicable laws and their institution’s policies. By ordering, you confirm that you are purchasing for legitimate laboratory research and agree to our Terms and Conditions.